Pure Forskolin, also known as Coleonol is a chemical compound extracted from a plant native to India and had long been used in Ayurvedic medicine for treatment of skin disorders and respiratory issues. However, recently it has been studied for possible effects on cardiac function, lung function, and glaucoma and also for weight loss. Forskolin is extracted from the Plectranthus Barbatus plant, also known as Coleus Forskohlii. Parts of the plant can also be made into a herbal tea which has been shown to possess some antioxidant and antibacterial activity.
As previously mentioned, the herbal tea derived from the plant has been shown to possess antioxidant activity as well as inhibition of bacteria which can cause dental caries. In addition, one animal study was able to show that it also has the ability to inhibit acetylcholinesterase, which may perhaps benefit those suffering from Alzheimer’s. Perhaps the most important benefit of Forskolin is its ability increase body levels of cyclic AMP or cAMP. cAMP is a molecule which helps to activate PKA or protein kinase A, an enzyme which has an extremely large range of biological functions in the body including control of glucose, protein and lipid metabolism, vasodilation and activating our reward system. As such, Forskolin has been implicated to help with reductions in blood pressure, to help treat glaucoma and perhaps even to help with colon cancer treatment. Perhaps the most interesting benefit of Forskolin for bodybuilders and for the average population is its potential to aid in fat loss. Because increases in PKA are also able to affect fat metabolism, there have been a few studies examining the potential for Forskolin to be used as a fat loss ingredient. Earlier animal studies have indeed shown that Forskolin was able to increase cAMP levels and as such was able to increase the level of fat burning. Human studies have been inconclusive however with some studies unable to show any changes in body composition to loss in body fat percentage and body fat mass in another study.